- Ariana Grande
- Artists in italics recorded new performances for the 2021 Big Weekend
- Billie Eilish
- Ed Sheeran
- Eric Prydz
- Phoebe Bridgers and Arlo Parks
- Bicep
- Coldplay
- Foals
- Harry Styles
- Stormzy
- Dua Lipa
- Floorplan
- Haim
- Jorja Smith
- Little Mix
- AJ Tracey
- Foo Fighters
- Honey Dijon
- Lewis Capaldi
- Lianne La Havas
- Jay-Z
- Lizzo
- Logic1000
- Royal Blood
- Thom Yorke
- Alicia Keys
- Griff
- Mabel
- Michael Bibi
- The 1975
- George Ezra
- Patrick Topping
- Shawn Mendes
- Tom Grennan
- Wolf Alice
- Celeste
- Dodie
- Lana Del Rey
- Paul Woolford
- Rihanna
- Charli XCX and Christine and the Queens
- Låpsley
- London Grammar
- Sam Smith
- Solomun
- Anne-Marie
- Clairo
- Hayley Williams
- Miley Cyrus
- The Blessed Madonna
- Alessia Cara
- Blossoms
- Years & Years
- Katy Perry
- King Princess
- Sam Fender
- Bring Me the Horizon
- Mac DeMarco
- Sigrid
- Doja Cat
- The xx
- Florence and the Machine
- Vampire Weekend
- Calvin Harris
- Glass Animals
- Twenty One Pilots
- Lady Gaga
- Kings of Leon
- Khalid
- Mumford & Sons
- Rex Orange County
BBC Introducing sets
Line-up from Wikipedia (CC BY-SA 4.0), plus sets added by TicketDay users. Spotted a mistake? Tell us.